Linear porokeratosis presenting in adulthood: A diagnostic challenge: A case report

Linear porokeratosis presenting in adulthood: A diagnostic challenge: A case report

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Linear porokeratosis is a rare gauze fabric by the bolt variant of porokeratosis that most often presents in newborns and children; development of this porokeratosis variant in adulthood is far less common.We report the case of a 25-year-old female who presented with a progressive eruption on the proximal upper extremity of 6-year duration, which was ultimately diagnosed as adult-onset linear porokeratosis and safely treated with oral isotretinoin.We propose that a sporadic mutation resulting in mosaicism after birth x515ea-bh55-cb may explain the development of linear porokeratosis in adulthood, although the exact trigger of such a somatic mutation is not known.

This case also describes a unique clinical presentation, with linear porokeratosis lesions originating on the proximal extremity rather than on the more common distal extremity.This demonstrates a distinctive clinical presentation not seen in the pediatric forms of disease.